Caloprid 1

Indication:
CalopridTM is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.

Dosage & Administration:
Chronic Constipation
Adults
2 mg once daily with or without food, at any time of the day. Due to the specific mode of action of Prucalopride (stimulation of propulsive motility), exceeding the daily dose of 2 mg is not expected to increase efficacy. Older people Start with 1 mg once daily; if needed the dose can be increased to 2 mg once daily.
Children
Prucalopride should not be used in children and adolescents younger than 18 years
Renal Impairment
The dose for patients with severe renal impairment (GFR < 30 ml/min/1.73 m2) is 1 mg once daily. No dose adjustment is required for patients with mild to moderate renal impairment.
Hepatic Impairment
Patients with severe hepatic impairment (Child-Pugh class C) start with 1 mg once daily which may be increased to 2 mg if required to improve efficacy and if the 1 mg dose is well tolerated. No dose adjustment is required for patients with mild to moderate hepatic impairment.